Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Stripping out price, volumes of Chinese imports in October fell a more modest 2.6 per cent from a year earlier, according to estimates from Oxford Economics.
十年前，斯蒂尔作为一名成功的投资顾问在世界电信展（ITU World）上发言。世界电信展是联合国主导的一项活动，重点是科技在政府中的应用。同一周，加州经历了史上第一次州长罢免选举。斯蒂尔不敢相信，在如此重要的选举中，会出现这种不合时宜的平台故障（三年前才刚刚发生了臭名昭著的佛罗里达州总统选举罢免），所以她决定凭一己之力来解决这个问题。到目前为止，共有169个国家使用了Everyone Counts的电子投票平台，包括波斯尼亚黑塞哥利亚和奥斯卡奖评审委员会。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
But researchers this year came up with a new method that makes flexible, realistic ears out of real cells. Those cells come from rats and cows, and they form a collagen gel that can take the shape of any mold. When placed in a mold of a human ear—a mold assembled using a 3-D printer—the gel forms an ear in less than an hour. The artificial ear then just needs a few days growing in nutrients before it's ready to be implanted in a subject.
China's Internet industry is often derided as a realm for knockoffs, especially of companies banned in China. Chinese search giant Baidu Inc. has a website that looks like Google Inc's. Tencent's flagship product, instant messaging service QQ, was launched in 1999 as OICQ and had similar functions to then-popular instant messaging service ICQ. Sina Corp.'s Weibo, a popular microblogging service, is invariably described as 'Twitter-like' in the Western media.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
To Craig Bennett, Abigail Baird, Michael Miller, and George Wolford for demonstrating that brain researchers, using a combination of complicated equipment and simple statistics, can find meaningful brain activity anywhere, even in a dead fish.
Perhaps the biggest domestic threat to the 3% growth scenario would be a surprisingly swift hike in interest rates, but from all indications a dovish Federal Reserve is unlikely to take aggressive action in 2015.
具有荷兰和美国双重国籍的Frans de Waal和另一位美国科学家Jennifer Pokorny获得这一奖项，他们的研究确认黑猩猩可以通过辨认同类的屁股照片来认出不同的个体。
Trends and targets in antiviral phototherapy
Last year he told an interviewer that 'among others' he would be giving his riches to Choupette.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Developer activity is also at a fever pitch. According to the contributor graph at GitHub, the total number of contributions to bitcoin’s master code in November was the highest it had been since spring 2012. Bitcoin is also the 31st “most forked repository” on GitHub—”forks” are basically proposed or in-progress alterations to core code—out of more than 900,000. In other words, for developers, bitcoin is trending. The number of open jobs currently posted at bitcoin companies also underscores developer interest: it’s at 105, which is close to the all-time high in September of 137, according to Bitcoin Pulse, which monitors such trends.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
13) I am often down in the dumps 0 1 2 3 4
ACE2 as a potential therapeutic target for pandemic COVID-19
Chinese Premier Li Keqiang delivers a government work report during the opening meeting of the fourth session of the 12th National People's Congress at the Great Hall of the People in Beijing, capital of China, Mar 5, 2016.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
There are, of course, complicated contours to 2016’s unusual politics. In Britain, immigrants from South Asia voted heavily to leave the European Union, citing hopes that curtailing European migration might open space for more people from Asia. In the United States, frustration with and alienation from status quo politics have helped drive Mr. Trump’s rise.
《沃兹汽车》将于1月15日在底特律一个与北美国际汽车展（North American International Auto Show）联合举办的仪式上颁发十大最佳引擎奖。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Specifically, the SAPPRFT said the total box office of China in 2016 reached 45.7 billion yuan (around 6.6 billion USD), an increase of 3.7 percent over 2015.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
We learned that nothing brings people together like the sun hiding behind the moon.
Set in 1950's London, Reynolds Woodcock is a renowned dressmaker whose fastidious life is disrupted by a young, strong-willed woman, Alma, who becomes his muse and lover.
Influenza neuraminidase: A druggable target for natural products
内森是少数几位在夜间拍卖会上积极出价的交易商之一。他在佳士得的拍卖会上代表一位客户以50.65万英镑拍下了查尔斯-安东尼·夸佩尔(Charles-Antoine Coypel)1737年的画作《阿米达宫的毁灭》(The Destruction of the Palace of Armida)，售价是预估价的两倍。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Whiteness, in this context, is more than just skin color. You could define it as membership in the “ethno-national majority,” but that’s a mouthful. What it really means is the privilege of not being defined as “other.”
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
戈尔迪·霍恩（Goldie Hawn）曾因影片《仙人掌花》（Cactus Flower）获最佳女配角奖，她的奖杯坐落在一个非常富有禅宗气息的地方——她的“印度房间”，她常在这里冥想。她的小金人并不是唯一一个和主人有共鸣的奖杯，罗素-克洛（Russell Crowe）曾在影片《角斗士》（Gladiator）中身着罗马战士裙装，扮演了一个威猛、极具感情和个性的古罗马战士--司令官马克西姆斯，他的奖杯放在鸡舍中，因为克洛相信小金人能够保佑母鸡下出更大的鸡蛋。
With its goal of universal healthcaresystem coverage by 2020, Chinais expected to transform the medicine market, becoming the second largest afterthe US.In the next five years, Chinaexpects per capita spending to grow by 70 percent.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
9．The Bling Ring
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
例如，佳士得给威尼斯艺术家弗朗西斯科·丰泰巴索(Francesco Fontebasso)在18世纪中叶创作的油画《井边的丽贝卡和埃利泽》(Rebecca and Eliezer at the Well)的最低估价为12万英镑。根据Artnet的数据，在1990年的拍卖会上，这幅令人愉快的洛可可装饰风格的油画是以28.6万英镑购得的。在12月8日的拍卖会上，它仅得到一个电话出价——11.5万英镑（不含佣金），约合17万美元。而投资者们可不认为在购买沃霍尔(Warhol)或巴斯奎特(Basquiat)的作品25年之后会损失约40%。如果一幅早期绘画大师的作品被搁置在交易商的画廊里，想转卖它就更加困难。
Inhibition of SARS coronavirus helicase by bismuth complexes
根据花旗居屋(Citi Habitats)提供的数据，在布鲁克林拟于明年投放市场的6527套新出租屋中，有1442套分布在贝德福德-斯图文森(Bedford-Stuyvesant)、布什维克(Bushwick)和克林顿山(Clinton Hill)。就在不久前，这些社区都还被视为不热门的地区。
Overall twenty-eight thousand bombs and other munitions were exploded over Yugoslavia a country the size of Ohio. William Cohen then secretary of defense characterized Allied Force as “the most precise application of airpower in history.” Some five hundred civilians died in the bombing a remarkably low number for such a high number of munitions expended. In its own account of the campaignNATO stresses that targets were “carefully sexted” and that “massive effort was made to minimise the impact of the air campaign on the Serb civilian population.”
The workers, who were part of a crew building a football stadium, were taken in the mainly Shi'ite Habibiya district in northeastern Baghdad.
Neneh Cherry “Blank Project” (Smalltown Supersound)
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Blake Griffin's high school appearance isn't that far off from how he looks today. Just add some hair and some size to his biceps, and you've got Blake Griffin today.
United States emissions had been declining because of increased burning of natural gas in power generation, which emits less carbon dioxide for each unit of energy than does coal. But the nation reported an increase in 2013 as coal regained some market share. If that trend continues, it could prove to be a challenge for the Obama administration as it seeks to institute tighter policies on greenhouse gases.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
They say that it is especially risky to use the same password for entertainment sites as for email and social networking accounts.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Beijing ranked No 3 on the list of top 10 most congested cites in China, following Jinan and Harbin, according to a report by China Academy of Transportation Sciences.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Insead is distinguished not only by its one-year programme but also a strongly international culture, based upon its two campuses, and one of the most extensive and diverse alumni networks. The programme is ranked third for the international mobility of its alumni and sixth for international course experience.
STEP 9: BE SURE to tell everyone to shut up on a daily basis, it's endearing you know
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Estimates for the size of the industry vary but Goldman Sachs figures suggest that sector loans grew from Rmb6bn to Rmb83bn between 2012 and 2014.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
As for China, lack or stopped development represents the biggest risk for this country. So it is essential that we maintain steady medium-high growth of our economy and that in itself is China’s contribution to global stability.
The other two tweets from Obama that made the list were posted when he was leaving the office.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
迷你剧集/电影类最佳女演员：萨拉?保罗森(Sarah Paulson)，《美国罪案故事：公诉辛普森》(The People v. O. J. Simpson: American Crime Story)
James Bond Themes 6. "A View to a Kill" by Duran Duran
Rogers, unhappy with the turn of events, decided to leave the show after the first three seasons. The breach of contract led to a multi-million dollar lawsuit. Ironically, Wayne Rogers had never signed his contract to begin with (he had a problem with a morals clause). The lawsuit was thrown out. You could say Rogers got the last laugh, but since M·A·S·H went on for eight more seasons and Rogers' never reached the same career success again, the last laugh might be a relative concept.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
But the crash hit. The economy tanked. The recession lasted 30 months. Wall Street lost over $8 trillion of our retirement money. In the first decade of the 21st century, from the 2000 dot-com crash till 2010 disaster Wall Street's had a negative inflation-adjusted performance. Today Wall Street's returns are just barely beating inflation. No wonder investors feel cheated by Wall Street's casinos.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
In the past 12 months, more than 20 provinces have introduced policies to encourage students to start their own companies by allowing them to quit studying but keep their student status for two to eight years. However, many industry insiders insist that students complete their studies and work a few years first.
6. It’s not that the story ended badly; it’s that we expect too much of the story.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The Great Recession had devastating effects across the U.S. and few places were as hard hit as Arizona. The state was booming on the strength of its tourism and real estate markets during the 2000s. Median home prices jumped 70% between 2003 and 2006—only Nevada had bigger gains—fueling more building and construction jobs. Monthly unemployment was at 3.5% through much of 2007. But then the bottom fell out. Home prices plummeted more than 50% from their peak and 6% Arizona properties received foreclosure filings in 2009. Unemployment stubbornly remained in double-figures for most of 2009 and 2010 and only Nevada lost a higher percentage of jobs over the last five years. Household incomes declined at the fastest rate in the country since 2008.
And among the GII 2016 leaders, four economies — Japan, the US, the UK, and Germany— stand out in innovation quality.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
This is a thorny issue that’s unique to messaging apps. We expect ads to live alongside content we consume. We don’t expect them to crop up in our one-on-one communications. “The last thing you want in a personal conversation is a banner ad or pop-up that interrupts that,” Wray says. “It might work with more impersonal networks, but specifically within messaging, people hate traditional ads.”
A modular microarray imaging system for highly specific COVID-19 antibody testing
After all, during the last round of collections, the most striking pieces — from Louis Vuitton, Dior, Proenza Schouler, Narciso Rodriguez — had a streamlined momentum that wasn’t dragged down by any decade-related reference, or identity. They were clothes that went striding into the future, freed from the weight of the past.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Employment is the foundation of economic development. It creates wealth and it is the major source of household income.
Russia and Nato have both called for a de-escalation of the Turkey-Netherlands row.
Jumping all in is rarely ever successful. There are success stories about people who invested everything once and came out winners after six months or a couple years, but those are rare. Risk management is an essential factor in any startup, and balance is vital. You can absorb losses more easily if you take smaller risks in the beginning. Those will provide essential and productive lessons.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
But Huy Vo, a senior specialist in public relations at Hawaiian, said the short flights, which make up half the airline’s routes, aren’t all that easy to operate. “Our geographic location certainly does give us an advantage, as well as our short-haul routes, ” Vo said. “However, the short-haul routes are the hardest to keep punctual, because the hops are very short, with brief ground time between flights, so any delay is difficult to make up.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
New Year time is here. I hope you have a wonderful New Year. May every day hold happy hours for you.新年来临，祝新年快乐，愿你时时刻刻幸福欢乐！
“…said he never lets people see him sweat — but he was sweating profusely.”
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
7. Make sure you don’t ask silly questions such as; is this Chelsea versus England?
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
She says she noticed the similarities between her and the Disney character when she first saw the film in December, calling the experience eerie.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The ‘one country, two systems’ principle needs to be steadfastly applied in Hong Kong without being bent or distorted.
All those totals are higher than a year ago, with the largest growth being in market value (up 13% year-over-year). These firms employ 90 million people worldwide.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Best chance: If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.
We learned that there is new hope for Africans with treatable cancers.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
1. What big brother is eating isn’t noodles, but loneliness.
1977：“俄罗斯型流感”H1N1感染人类1977: "Russian flu" H1N1 Infects Humans
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
In local currency terms exports managed slight growth of 0.6 per cent last month, besting expectations of 0.1 per cent contraction but still down substantially from growth of 5.9 per cent in November. Imports grew 10.8 per cent in renminbi terms, more than double the expected 4.8 per cent but down 2.2 percentage points from the month prior.
6. “Taxi”(Jafar Panahi)
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The number of candidates for the 2016 national civil service exam has surpassed last year's numbers, with more than 132,000 applicants on Tuesday－the most in a single day－deemed qualified for the exam.
The results are based on a survey of 15,870 people across the country in August and September.
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We will make a big push for progress in the reform of the social system.