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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

事实是,韩力不是第一个发明电子烟的人。早在1963年,赫尔伯特·吉尔伯特就制造出了世界上第一个可以用来吸入香烟味儿空气的装置。他最初的发明装置,不用燃烧,也不含尼古丁。他后来设计出了一个用电池去加热的模型,他也用了不同味道的水去制造蒸气。他把他的电子烟模型展示给不同的化工、制药以及烟草公司,但是他们都没有理会他的模型。
Henda Ayari

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

但是人造胰腺能够自动释放胰岛素到你的身体里。这个装置看起来像一个规律的胰岛素泵,它可以穿透皮肤连续地释放胰岛素进入身体。而且它一直监视血液里的血糖含量,并根据血糖含量调整胰岛素释放量。所以,即使携带该设备的人睡着了,也不会有血糖降至很低而晕倒的危险。
They need more talent. Full stop. The best avenue for attracting talent for them has always been the draft.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

3.Video Editing: 19.2 percent increase

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Star Wars: Rogue One is set to release on December 16, 2016.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 乐居发布“1+1+7”全新业务战略
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

n. 锦标赛,冠军,拥护
2015年英国《金融时报》全球高管工商管理硕士课程(Global Executive MBA,简称全球EMBA)排行榜由于两个原因而引人注目。不仅因为这是英国《金融时报》发布的第100个商学院排行榜,也是因为今年首次有一个主办方包含一所中国内地商学院的项目拔得头筹。
进入2月以来,猛龙逐渐感到他们需要进行人员调整了:良好的开局已经被挥霍的差不多了,他们的防守不足以限制对手,他们在四号位有个巨大的漏洞,在凯尔-洛瑞即将成为自由球员之前,他们急迫的需要利用好他的巅峰期。
I’m not saying you should blindly accept everything that’s offered to you, it’s okay to take time when considering the pros and cons of an opportunity. But, when you find yourself leaning toward “No,” you owe it to yourself to be sure that you’re turning down the opportunity for a valid reason, not just out of fear.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

周日也就是张天羽的作品被谷歌展示的前一天,她接受纽约长岛报纸《新闻日》的采访,表示自己对获奖感到兴奋,但不会熬夜等自己的作品上线。
Emissions have been falling gradually in recent years in most of the developed countries, in part because of economic weakness but also because of strengthening climate policies. Emissions in the 28-nation European Union fell 1.8 percent in 2013, despite increases in coal consumption in a few countries, including Germany and Poland. Emissions decreased sharply in Britain, Italy and Spain.
There are two divergent views of what is happening to the oil price ithin the industry and among serious investors. 2016 may help us to see which is correct.
Peace and love for you at New Year from all your students.祝老师新年充满平安和爱。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

“We had to make Steve look like a blue-blooded man of great family wealth,” Mr. Corso said. “There’s a specific look, a definite visual that goes along with that.”

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

proper拥有+ty→财产;所有物;特性

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

林怡仲预测道,下半年A股IPO的数量或将维持与上半年相当,预计2016年全年A股IPO为120宗左右,融资规模在600-800亿元人民币左右。
要大力弘扬工匠精神,厚植工匠文化,恪尽职业操守,崇尚精益求精,培育众多“中国工匠”,打造更多享誉世界的“中国品牌”,推动中国经济发展进入质量时代。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

The economy has registered a slower but stable performance with good momentum for growth.
n. 路线,(固定)线路,途径

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Quiz
但来自宾夕法尼亚州(Pennsylvania)的玛蒂?齐格勒(Maddie Ziegler),她的人生完全不是这么一回事。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

《好时光》
trademark
"Under the leadership of the CPC Central Committee, we'll broaden judicial cooperation with relevant countries so that there will be no 'safe heaven' for corrupt fugitives," said La Yifan, director of the CCDI's International Cooperation Department.
The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 借力资本市场 家居行业整合加速
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

谎言5:你穿这条裙子真好看。说谎原因:总比说真话被别人扇耳光要好吧。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

影片评价极高,演技也大获好评,尤其是故事的主人公——那些孩子们,以及汽车旅馆经理的扮演者威廉?达福。
The reason is twofold: For one, logistically, there are simply too many opportunities to get caught job searching. Résumé copies will be found. Computer servers will be checked. Co-workers will notice when you're clearly elsewhere, either literally for interviews or emotionally (more on that later)。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

That is changing. One big 2013 move for benchmark Brent crude came in August, when international intervention in Syria seemed increasingly likely. But while the price of Brent, which is traded on London's IntercontinentalExchange, did rise by 5% on the threat of U.S.-led airstrikes, it didn't come close to the 2013 high.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

[k?m'pein]

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

荷兰首相马克?吕特(Mark Rutte)最近由于对安卡拉立场强硬而在民调中排名上升。吕特所属的自由民主人民党(VVD)在民调中略微领先自由党。周二,他将埃尔多安的言论称为“对历史令人恶心的歪曲”,还称“我们不会自甘堕落至这种水平。这完全不可接受”。
听起来像是泰勒斯威夫特,但事实上,却是她一直以来的竞争对手,凯迪派瑞。这主要归因为她的棱镜世界巡回演唱会。现在演唱会的热潮已归于平静,派瑞今年凭此吸入13.5千万美金。在我们评分期间的126场演出中,她平均每个城市赚得2百万美金,再加上与科蒂,克莱尔和封面女郎的合约,得到了她的总共收入。
Brazil's President Dilma Rousseff, who is facing impeachment, slashed her own salary by 10% to $103,400 a year last October as part of a wider austerity drive.
7. Pumping Iron Could Enhance Long-Term Memory

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

n. 行星
在新兴市场出口量方面,巴韦贾不排除增长约4%至5%的可能性。但是,尽管与近年来相比这将是一种温和改善,但这一增长速度仍“处于长期分布中的最差25%区间,甚至可能是最差20%区间”,因为过去25年的年增长率中值约为7%。
['v?ksi:n]
The data highlight the growing anxieties in some sectors of industry about what they see as unfair competition from Chinese rivals.
The most staggering scene is, of course, that in which the alien picks up a young man with the facial condition neurofibromatosis, played by Adam Pearson. Glazer brings to this scene an utter fearlessness and unsentimentality, perhaps a variation on a theme from David Lynch’s The Elephant Man. The alien does not essentially distinguish between his looks and those of her other victims, but her encounter with him – an encounter of two aliens? – triggers a crisis in which she becomes the prey rather than the hunter.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Overall, 36 percent point to end times and 63 percent to climate change.
《为奴十二年》导演史蒂夫?麦奎因(Steve McQueen)在登台领奖时说:我有点吓到了。然后他微微耸肩,引用片中福音歌曲的歌词,说了句“翻涌吧,约旦河,翻涌吧”("Roll, Jordan, roll")。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

我发现自己很难开启一段对话

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

你有D型人格特征吗?有测试表明,拥有这种鲜为人知的性格的人非常善于隐藏情感,甚至他们自己都没有意识到自己很孤单、很焦虑。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

The current El , a naturally recurring phenomenon that warms the Pacific Ocean, was probably only responsible for about 10 per cent of 2015’s record-breaking temperatures, he added.
那些具有3年驾驶经历,无重大交通事故、危险驾驶、吸毒、酒驾记录的司机将可参加网约车考试。
在即将结束的2014年,标普500指数再次实现亮眼增长,而那些本欲跑赢该指数的基金经理们,表现则没那么出色。Lipper公司称,截止11月底,85%的活跃股票型共同基金经理业绩低于标普500指数。而在正常的年份里,跑赢该指数的基金经理比例是今年的两倍,也就是说,通常只有约三分之二的基金表现不如标普500指数。Lipper公司称,这是30年来活跃基金经理相对大盘表现最差的一年。
In 2017, his 14th season in the league, LeBron James averaged a career high in assists and rebounds. In the first two months of 2017-18, he's averaging a career high in 3-point percentage, but that's been talked about and dissected; it's been written about extensively.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

n. 枝,杆,手杖
"Their political leanings are even affecting how they experience weather, which is pretty fascinating," said Cox.
本周二,年仅17岁的Thomas Sohmers推出了一个全新的高速计算机服务器,该计算机功耗极低,该计算机使用了低能耗的ARM处理器,而其所需电量仅为一台普通电脑一小部分。在本周在旧金山举行的Open Compute Project (OCP)大会上,Sohmers展示了这台服务器。这个产品是Sohmers所创办的企业REX所推出的第一个产品,REX的另一位创始人为52岁的Kurt Keville,目前Keville担任公司的CTO。
8. Pour-Protection by Pet Life

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

adj. 群众的,大规模
在苹果今年6月举行的全球开发者大会(Worldwide Developer Conference)上,库克被应用开发者团团围住,要求与他自拍合影。到了10月的iPad发布会,他甚至自己讲起了笑话。他还是一贯的着装,简单朴实:黑衬衫,牛仔裤,衬衫下摆散着。他说,Apple Watch得到了“深谙时尚与风格——比我还懂的人”的热烈好评,一边说,一边心照不宣地指着轻声发笑的观众。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

谎言2:好的,我会尽快开工的!说谎原因:如果我告诉你在做你要求的这件事之前,我还有10件事要做的话,你肯定会抓狂的。
Plante Moran
还有仅仅9所商学院参与了所有4项排名。它们的排名从第三(西班牙企业商学院)到第38位(米兰理工大学MIP管理学院(Politecnico di Milano School of Management))不等。
About 200 million migrants, half of whom are women, sent $445 billion to their families in Asia, Latin America and Africa in 2016, the International Fund for Agricultural Development (IFAD) said last Wednesday.
上海软科教育信息咨询有限公司于上周三发布的2018年“世界大学学术排名”显示,中国有62所研究型大学入围这份全球500强高校榜单。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Whether China opens the stock floodgates or not will be a major price-driver in cotton and sugar — and potentially also in corn, soyabean or vegetable oil — markets in 2017, the bank said in its report.
37岁的吉赛尔·邦辰赚得1750万美元,排名第二,自2002年以来这是她第一次没有登顶模特收入榜单。
如果你认为一开始准确判断应增持和减持哪些行业的股票是件难事,在年内不断调整投资组合更是难上加难。11月,野村证券一位定量分析师向《巴伦周刊》表示:“行业领军者每个月都在变换,其变化速度之快,在股市数十年未见。即便你选对了某行业的个股,由于市场环境瞬息万变,业绩也根本无法持续。”

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

愿你拥有新年所有美好的祝福。
'My first duty, my first responsibility was to be true to the original feel of the book, to be true to Ian Fleming: his creation, his world and his ideas.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

3.葡萄牙波尔图
可口可乐表示,中国消费放缓打击了销售额,而较为疲弱的需求正迫使其降低库存。
这两部极具娱乐性,追求整体效果,建立在事实基础上的程序剧(procedural)都是关于惊人的犯罪与腐败滋生的大型机构的故事——一个是关于罗马天主教会,一个是关于华尔街银行。除了激发起正直的愤怒,麦卡锡与麦凯以不同的方式,把悬疑、情感和道德的分量融入到接电话、敲键盘、读报表等现代日常工作中去。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Floodwaters surround homes near the Mantoloking Bridge the morning after Sandy hit Mantoloking, New Jersey.
port部分+ion→一部分→部分,一般
从1970年到今天,世界各地的文盲减少了50%。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

独裁者利用前者作为镇压的借口,利用后者要求绝对服从。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Whenever I talk to people about the future, I'm struck by their belief that it is knowable. The impression I get is that most people imagine the future like a book ending: already written and readable if you can just steal a quick look at the last few pages. What they find difficult is accepting that the pages aren't written yet. The future hasn't happened, hasn't even been planned--and cannot be known because it doesn't exist.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Index: 96.6
The secretive billionaire who launched a hostile takeover bid for China’s largest property developer has emerged as one of the country’s richest people, illustrating how leveraged financial investments are propelling huge increases in private wealth.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

A Pioneering German Feminist Looks Back in Anguish
《生活大爆炸》中绝不缺少天才。不只是因为这部剧向观众展示了很多绝顶聪明的科学家,同时,演员玛伊姆·比亚利克还拥有神经学博士学位。因此,演员们想要在剧中展示他们的聪明才智,并将整部剧做到精益求精,这也不足为奇。剧中谢尔顿和莱纳德的公寓里有一块很大的白板,这对铁哥们几乎在处理任何事时都会用到它,从完成从学校带回来的工作,到决定是否等到看完最新一部《蜘蛛侠》再吃饭,都离不开这块白板。
Jennifer Lawrence is one of the hottest young actresses in Hollywood right now, so it's no surprise that a lot of men find her to be irresistible.
A Sicilian Photographer of the Mafia and Her ‘Archive of Blood’

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

尽管欧洲工商管理学院与清华大学的合办项目重新跌至亚军位置,但欧洲工商管理学院自己的EMBA项目的排名却上升3个位置,排在第四位,该项目上次获得第4名是在2011年。
The actress posted on Instagram a seemingly heartfelt missive after the attacks in Nice and Turkey. But she paired it with a photo of her in some skimpy lingerie attempting to look seductive.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Most entrepreneurs (78 per cent)used savings or relied on friends and family to raise all or part of their start-up funds. Angel financing was also a source for a quarter of entrepreneurs.
先锋(Vanguard)的亚洲投资组合审查主管Yan Pu怀疑,亚洲的产品结构可能阻碍了ETF的发展。例如,亚洲ETF公司提供大量的股票ETF产品,但很少有固定收益产品。她指出,在美国,固定收益ETF增长迅速。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Yang Yansui, director of the School of Public Policy And Management at Tsinghua University, said the four-trillion-pension balance was mostly in personal accounts, while the pay-as-you-go pension system was greatly challenged by dependency ratio.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

While the WeChat use of the "post-90s" generation has slightly decreased, from 94.1 percent to 86.6 percent.
我们希望看到的亚太地区是一个稳定、有秩序的地区,是一个可以协商一致、达成原则的地区,是一个有能力管控分歧的地区,也是一个有智慧解决争端的地区。
Wang said the journal and authors had an unavoidable responsibility in the latest scandal, with the statement adding that Tumor Biology had retracted papers over similar concerns about the peer review process in 2015.
Its corporate customers value the school’s flexibility and ability to innovate. “We have developed a programme which is co-delivered with an experimental learning provider,” commented one client responding to the FT survey. “Iese has been a true partner in this process and our business has benefited with an energised and prepared executive bench.”

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

赢家:鹈鹕
纸筒插秧机可以让一名使用者在几分钟内在85英尺(约合26米)长的一块田地里种植264棵幼苗。这在以前通常耗时数小时,如今只需几分钟。使用者在种植农作物上花费的时间更少,可以节省出更多的时间做其他的事,比如农田改进、市场销售、或者干脆休息休息。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

推进农业结构调整。
因城施策去库存。
More than 40 percent of consumer goods exported to China last year through e-commerce platforms fell short of standards, China's top quality watchdog said.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

我们准备今年在香港和内地试行“债券通”,也就是说允许境外资金在境外购买内地的债券,这是第一次。香港是近水楼台先得月。
10. Taitung, Taiwan-The footbridge which connects small, uninhabited Sanxiantai Island to Taitung is celebrated for its eight looping arches. This coastal county is in Lonely Planet's list of top destinations in Asia to visit in 2016.
Since then, Teach First has put 5,000 graduates into schools, working with more than 1m pupils in low-income areas, helping to raise standards in classrooms, particularly London.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 北京别墅市场开启“竞配赛”
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

pressure
Obama's victory in the hotly contested swing state of Ohio - as projected by TV networks - put him over the top in the fight for the 270 electoral votes needed to clinch the White House and ended Romney's hopes of pulling off a string of swing-state upsets。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 2018年智能家居市场有望达1800亿元
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

这家总部位于伊利诺伊州皮奥利亚的重型机械制造商于1月份批准了100亿美元的股票回购,预计将在今年一季度回购17亿股股票,以完成先前75亿美元的回购计划。公司CEO道格o奥伯赫尔曼表示,正在进行的回购是“我们的现金流创纪录的结果”。(财富中文网)
这几年的实践可以证明,中国经济“硬着陆”论可以休矣。我们会长期保持中高速增长,并迈向中高端水平。
For: Strong reviews, and praise for the performances - particularly from the children at the centre of the story, and Willem Dafoe, who plays the manager of the motel where they live.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 2014年建材加盟专业报告指南
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

法国巴黎高等商学院排名第二,尽管该学院在除MBA以外的所有排名中都胜过伦敦商学院。法国巴黎高等商学院最终不敌伦敦商学院的原因是,其高管MBA课程Trium是与伦敦经济学院(London School of Economics)和纽约斯特恩商学院(Stern School of Business)合办的,因此这门课程在该项排名中的得分只有总得分的三分之一。(合办课程的商学院参与EMBA课程排名时按比例获得分值。)
报告称,打造“机遇之城”的关键是技术创新和均衡发展。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Nothing Gold Can Stay
7. Your company's human resources staff saw your résumé on a job board。
乔斯·威登一直都很喜欢科幻小说,也是西部小说的忠实拥趸。尽管这两种小说类型风马牛不相及,但是从《天使杀手》这部书中,他找到了一种方式,可以把二者融合起来。"我当时想把新垦地的概念好好地演绎一下",他说,"人类文明是由那些被历史深深伤害了的人们推动前行的,而不是那些创造历史的伟人。"这一次,威登决定把新垦地从西部搬到了"宁静号"宇宙飞船上。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

差不多人人都知道谷歌的分析工具Google Analytics,但是你是否用过谷歌的网站管理员工具(Google Webmaster Tools)?作为一名营销人员,我认为谷歌的网站管理工具是我用过的最重要的免费工具之一。你肯定想让自己公司的名字出现在谷歌搜索结果之中,对吧?那么为什么不听听谷歌网站管理员工具教给你的诀窍呢?

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 收紧贷款别让刚需躺枪
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

I'm assuming they'll end up around the No. 10 pick at this point; it's hard to get an instant franchise player that low, and New Orleans doesn't have all the time in the world.
Golden State Warriors point guard Stephen Curry said he has visited China every year since 2013 and the fans there are incredibly supportive.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

The French president would have ranked much higher had he not taken a 30% pay cut on assuming office in 2012.
3.8 推进以保障和改善民生为重点的社会建设

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

信息技术是第三大行业,有18个入围品牌。上榜IT品牌的总价值占到了榜单的22.5%.平均价值上升了10%。北京是IT行业总部的首选位置,有12个上榜IT品牌的总部设在这里。
TAXES: Approximately $18,036 a year

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

1. Cannes has a dirty underbelly
"Pandas used to be really difficult to breed in captivity, but the Chengdu base and other zoos around the world have cracked the problem and now there are around 400 in captivity," Mr Marven said.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

The Education Ministry has also taken some measures, such as canceling testing results and noting cheating in personal records.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

不过,日本央行(BoJ)仍决定不加大货币政策刺激力度。该行指出,工业产出是日本经济疲软的领域之一。当然,就业市场等日本经济的其他领域,表现要好得多。
4.闻疾病的鼻子
Martha Cherry took a cigarette out of her mouth, murmured, "I've been there," and resumed smoking. Marc was in shock (which, let's face it, is a pretty healthy response when you realize your own mother may or may not have had thoughts of murdering you while you bathed). He realized for the first time how desperate and lonely it could be to be a housewife. He realized then and there that he was upon a very good idea for a TV show. This conversation was the birth of Desperate Housewives.
注:本文转载自前十网,译者:Carrie

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

February 1985 was the last time global surface temperatures fell below the 20th-century average for a given month, meaning that no one younger than 30 has ever lived through a below-average month. The last full year that was colder than the 20th-century average was 1976.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

全国31个省(区、市)1767所高校43万多名学生接受了调查。89.2%的受访者曾考虑过创业,18.2%的受访者称有强烈的创业意向。
Sebastian Payne
8.《生活大爆炸》白板上的公式都是真的

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

The excitement was triggered by a Reuters story that cited documents about the potential transaction as the source of its information. Samsung actually has made at least one play for BlackBerry BBRY -19.77% before, in 2012. As to this latest rumor, the alleged takeover target was the first to refute that a deal is in the works.
6. Our last universal common ancestor gets a makeover

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

一位著名神经学家的遗作引发的争议
Wang Jie, the general manager of a Beijing-based investment company, said the higher pay for executives in the financial and real estate industries shows the imbalance of development in China.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 2016年陶瓷砖产量完成110.76亿平米
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

请接受我节日的祝贺。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

今年临近尾声之际,欧洲央行在12月3日投票削减其存款利率至负0.3%,并扩大资产购买,使量化宽松计划的规模达到1.46万亿欧元。此举出炉十几天后,美联储(Federal Reserve)自2006年以来首次提高利率,突显大西洋两岸正在推行的货币政策截然不同。
维多利亚的秘密内衣秀刚刚拉开华丽巨幕,今年的秀也是有史以来最奢华复杂的一次。
The state-sponsored purchasing managers' index fell from 50.8 in October to 50.3 in November, the lowest reading since March. Any level above 50 indicates expansion.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

['b?t?flai]
TOP SONGS
这四个特大城市在11月之后则经历了交通拥堵状况的缓解,这可能与冬季用户出行减少、雾霾、外出打工人员返乡等多重因素有关。
People were busy launching businesses or making innovations.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Rose McGowan accused producer Harvey Weinstein of rape this time last year, sparking an avalanche of allegations in the entertainment industry and beyond.
据《21世纪经济报道》称,广东去年的GDP增速为7.5%。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The kitchen addition, about 40 feet long, was designed to be in keeping with the original house, with intricate ceiling woodwork and several colored-glass panels by Century Studios, a Minneapolis company that secured its glass from the Chicago manufacturer used by Frank Lloyd Wright. Stainless-steel appliances include a five-foot-wide range and a Sub-Zero refrigerator. The dining area opens to a back patio through 10-foot-tall glass doors.
WHAT: A Greek Revival with four bedrooms and four and a half bathrooms
凡是这家汽车服务公司的忠实员工在效力满10年后,都可获得一份奖励:在佛罗里达州波卡拉顿的一处度假胜地欢度周末(此地距该公司总部仅15分钟车程)。这项福利此后每5年都可以享受一次。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

在开放课程排行榜中,基于对参加课程高管的调查,瑞士洛桑国际管理发展学院在最重要的10项指标上得分特别高。该校在3项指标上排第一,在其他7项指标上都排前五。
之所以会出现这一较低读数,是因为产量因素出现了下跌——尽管前瞻性新订单因素连续第6个月上升。

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